Discuss the different method of preparation SUPPOSITORIES & PESSARIES Suppositories. 622–623. So, the weight of the suppository base is 14 – 3=11 gm. 8. sodium salt of phenobarbital is the preferred form of the drug to use. Increased productivity.Working with computers reduces the amount of time taken to have results. Discuss … Explain various types of suppository bases. Give merits & demerits. The rate of bioavailability differed markedly between products and, in one case, the suppository dose of acetaminophen was so slowly absorbed that the clinical effectiveness of the product is doubtful. Discuss method of compounding with example. LWBK127-C24[291-297].qxd 10/19/2008 12:42 PM Page 296 Aptara Inc. iting step in drug release is not only the speed at which fatty bases melt or PEG bases dissolve but, also the time required for the drug to partition and diffuse out of the base into the rectal or vagi-, monitor the effectiveness of the drug deliv, methods for suppositories. Give any four merits (advantages) of suppositories. Some Acids are highly corrosive in nature which means that they corrode or rust metals. The first is drugs that can also be found in legal pharmacies and street markets. All rights reserved. What are the characteristics of an ideal base? Syllabus Introduction, definition, advantages and disadvantages, desirable features of suppositories, factors affecting rectal absorption. © 2008-2020 ResearchGate GmbH. We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. Suppository bases can be broadly divided into following categories- A. Oleaginous bases. Give any four ideal properties of suppository bases. 3. [8] (2001, 1998) 2. So, by the addition of the drug , 1 gm of the suppository base is displaced. ing difficulties as are seen with cocoa butter. imparts excellent mold release characteristics. √ Fatty (oleaginous) bases ... Pharmacist should calibrate each suppository mold for each base. ... Classify emulsifying agents and discuss them. ed. A common trade name is carbowax. Some drugs are stolen from pharmacies by employees and sold in the street market at a cheaper price. 5 5 Marks 5. Boric acid is often used as an antiseptic, insecticide, flame retardant, neutron absorber, or precursor to other chemical compounds. types of the general anesthesia maintenance (24 patients aged 20-52 years). *Density measurements done at 20° for those grades that are liquid at that temperature (300, 400, 600). Actually there is a fluent transition between the numerous so-called „butter "-raw materials on the market. Describe the various parts of a prescription 6. Classify suppository bases. They are reported to support mold or bacterial growth, PEG suppository bases are formulated so they do not melt at body temperature but rather dis-. Their in vivo performances--pharmacokinetics and pharmacodynamics--were evaluated in rabbits. Classify suppositories Advantages & disadvantages of suppositories. 7. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. 4. 2. The Roxy market in the Adjamé district of Abidjan in Côte d'Ivoire is well known among the city's poor people. Classify suppository bases. Classify Suppository bases. Discuss in brief any one suppository base. 6. changes in weather that can affect their quality. Define and classify dosage forms. In: University of the Sciences in Nearly all the vendors are women, and more than a third are illiterate. All types of suppositories are melt at normal body … Suppositories 2 Marks 5. Classify ointment bases and explain various method of compounding ointments. 2008 USP 31/NF 26. Suppositories have a base made from substances like gelatin or cocoa butter that surrounds the drug. and ethoxylated partial fatty glycerides (4). SUPPOSITORY It is solid dosage form meant to be inserted into Body cavity like rectum , urethra, vagina, where they melt or soften to release the drugs and produce their local or systemic effect. In addition, some drugs made in Europe are in the street market—probably sold on by unscrupulous Europeans—even though domestic manufacturers are licensed to make the same drugs.The second category is the drugs found only in the illegal street markets. Suppository bases specifications and desired‐ features, classification and selection of suppository bases, special bases… What are the steps √ Prepare molded suppositories from base material alone √ Remove and weigh H15 grade is the most readily available to pharmacists. The use of combined anesthesia and premedication with suppositories containing phentanyl, methacin and etaperazine under the conditions of monohalothane anesthesia makes it possible, upon the attainment of stage III1 anesthesia, to reduce the concentration of the fluorine-containing anesthetics in the venous blood of the children by 1.7-1.8 times on an average. -- -'- -J ( l0) (b) Define the Displacement value. parameters were determined from the plasma concentration-time profiles using a model-independent computer programme, RAMKIN. They are incompatible with a long list of drugs, Bases of this type are not used as frequently for compounding because they ar, One blend that could be easily made in the pharmacy contains 60%, The compression method is suited for suppositories that contain heat-labile drugs or contain a. LWBK127-C24[291-297].qxd 10/19/2008 12:42 PM Page 297 Aptara Inc. ResearchGate has not been able to resolve any citations for this publication. urated fatty acids in the C-12 to C-18 range. Water soluble or water miscible bases: – these dissolve or disperse in rectal secretion, e.g. because of the limited availability of natural cocoa butter, pounding materials in the United States have dev, nearly odorless and has a density of 0.95 to 0.98 at 20. and will absorb a small amount of water (4,8). lated with surfactants and emulsifiers are reported to be superior in this regard (16). Using cannabis to treat medical conditions is gaining in popularity and acceptance every day. Give merits & demerits. The delivery cars operate at night or early in the morning. See our User Agreement and Privacy Policy. King JC. (2 x 10 = 20) Write short notes: 3. 7… The absorption of acetaminophen from the suppositories was extremely variable and showed relative bioavailabilities of 68.4 to 87.5% when compared to the oral absorption of the drug from the tablet. Oleaginous Bases. Compounding rectal dosage forms. Define suppository. Each … After being diagnosed, it was managed by diclofenac sodium suppositories. Define suppository. Acids tend to evolve hydrogen gas whilst reacting with an active metal such as Zn, Mg, etc. A. Oleaginous bases: Theobroma oil or cocoa butter was introduced as base in 1852 and has been one of the most widely used bases. Let us get started with acids, 1. Chickenpox has many rare complications; transient synovitis is one of the very painful and self-limiting rare complications. It contains emulsifiers to allow absorption of small amounts of aqueous solutions. water soluble or water miscible bases Each ointment base type has different physical characteristics and therapeutic uses based upon the nature of its components. Medicated topicals. 1. It is comes under semi solid preparation because it is prepared by melting all ingredients (bases and other additives along with active ingredient). Define ointment. A. Theobroma Oil or cocoa butter is used as a suppository base because, in large measure, it fulfills the requirements of an ideal base. Bases 4 and 5 have been used for progesterone suppositories. Fatty bases – they melt at body temperature. The United States Pharmacopeial Convention, Inc. Front matter—NF: Excipients. These are drugs that have escaped government regulation and are essentially those smuggled into the country past customs agents (or with their connivance). These products will be classified on a case-by-case basis. Base 6 can be used for water-soluble drugs. Define and classify suppositories. Author, 2006. Cocoa butter does not contain emulsifiers. The United States Pharmacopeial Convention, Inc. Chapter 〈1151〉. Dispensing of medication, 9th ed. ** 10 Marks 3. water-soluble ionized (salt) forms of drugs should be used when possible with fatty bases. You can change your ad preferences anytime. It has a melting point range of 32°C to 36.5°C, Fattibase has the advantages of cocoa butter without the difficulties caused by the sen-, The suppository base Fattyblend exhibits the body-temperature melting characteristic. Suppositories 2 Marks. Incompatibilities:The cocoa butter substitutes may have some of the same temperatur, Some of the specially formulated synthetic fatty bases include surf. They are usually not registered in Côte d'Ivoire and mostly come from Ghana, Nigeria, and India. In: King RE, ed. As the warmth of your body melts … by the addition of 4% to 6% white wax or 18% to 28% cetyl esters wax, exact amount that will give an appropriate melting temperature can be difficult and time con-, emollient and is used alone or in topical skin products for this property. Allen LV. Philadelphia, ed. 2. 3. Acids change the colour of litmus from blue to red. Suppositories. In vitro and in vivo studies on slow release propranolol hydrochloride suppositories. Define suppository. Suppositories are composed of an active ingredient within what’s called a suppository base. With hundreds of vendors, it is a vast expanse of shelters and parasols under which all kinds of drugs in all sorts of forms—pills, syrups, powder, suppositories, injectables, ointments—are displayed in a jumble on tables or in baskets. Dispensing of medications, 9th. Colors C. Perfumes D. Surfactants; The HLB (Hydrophilic – Lipophilic Balance) System is used to classify emulsifying agents or surfactants based on their polarity. C. Emulsifying bases. the water absorption properties of cocoa butter (7). The major classes are the coating additives, emulgents, taste and smell-improvers, ointment bases, antioxidants, consistency or viscosity enhancers, and disintegrating materials. Classification of suppository bases. Define prescription. These products will be classified on a case-by-case basis. Define Galenicals; Explain about Percolation process and Maceration process? Suppository bases may be classified into: Oleaginous bases (fatty) Water-soluble bases (dispersible) b) Classity the suppository bases. Dispensing of medication, 7th ed. Secundum Suppository bases may be conveniently classified as according to their composition and physical properties: Oleaginous (fatty) bases Water soluble or miscible bases 6. inherent in cocoa butter without the polymorphism. The HLB system is used to classify: A. Classify the surgical dressings and write a note on Absorbent … Give any four merits (advantages) of suppositories. illustrated with Sample Prescription 31.2 in Chapter 31. is not a good choice for the suppository base (11). 2. The United States Pharmacopeial Convention, Inc. Chapter Chloral hydrate suppositories. Area under the concentration-versus-time curve (AUC) was comparable between the syrup and the 50-mg suppository and between the treatments with two 12.5-mg suppositories and the 25-mg suppository. Rockville, MD: For instance, they may contain glycerin to treat constipation or acetaminophen to treat a fever. The Food and Drug Administration (FDA) has established classifications for approximately 1,700 different generic types of devices and grouped them into 16 medical specialties referred to as panels. In the pharmaceutical context they serve as ointment and suppository bases or tablet additives. 2005; 883-886. Rockville. It has a melting point range of 34°C to 37°C. 7. Plaxco JM. Write the definitions of solid dosage forms used internally and externally. forms, therapeutic results should be monitor. While smoking, vaping, edibles, and topical applications are very familiar the use of suppositories is still in the shadows and a relatively unknown alternative. Personal communication to the. Bases of carbon, nitrogen and oxygen without resonance stabilization are usually very strong, or superbases, which cannot exist in a water solution due to the acidity of water. This method offers the possibility to make suppositories of many shapes and sizes. positories should be moistened before insertion. What are the ideal requirements of a suppository base? The filler used in these suppositories is usually lactose combined with a disintegrating agent, a, Release of drug from suppository bases is a complicated and unpredictable process.The rate-lim-. Am J Hosp Some wholesalers have set up a supply system to the illegal outlets so that all the groups of drugs present in the legal pharmacies can also be found at cheaper prices in the illegal market. None has knowledge of drugs or any medical training—but this does not mean they aren't ready to quickly diagnose an illness or try to decipher a prescription so they can provide a drug, though their choice is more likely to be determined by what they have in stock than the actual cause of the illness.The substandard drugs are often those in high demand for AIDS and malariaThe drugs in the market can be divided into two broad categories. Explain formulative additives used in Biphasic liquid dosage forms? Classify suppositories Advantages & disadvantages of suppositories. SEMI SOLID PREPARATION SUPPOSITORY PRESENTED BY MANOJ KUMAR M.PHARM (AMITY UNIVERSITY) Page 1. If you continue browsing the site, you agree to the use of cookies on this website. Learn about these drugs, the risks, and more. in many pharmacies. SUPPOSITORIESRakesh Kumar Sharma Rakesh Kumar Sharma 1 2. Water-soluble or water miscible base – they dissolve or disperse in rectal secretions. Indeed, the legal pharmaceutical sector supplies about 48% of the stocks of drugs in the country's illegal street markets (www.remed.org/fichiers/ReMeD22.pdf). Source: The Dow Chemical Company, Carbowax and Carbowax Sentry Product Data Sheets (http://www. the cocoa butter melt is given with example 31.1 in Chapter 31, release of some drugs.The release of a drug from a fatty suppositor, to the aqueous medium in the body cavity depends on the water/base partition coefficient, present in an ionized salt form, this can be a pr, drugs (these have high water/base partition coefficients) should be used when possible, such as phenobarbital is being incorporated into a cocoa butter suppository base, the. lowering of drugs such as chloral hydrate. Discuss in cletail warersolLrble suppository bases (lU; Q'5 a) Define and.classify oftrcial syrups. 4. Remington: The science and practice of pharmacy, 21st ed. Pastes are generally dispensed in single-dose oral syringes, or in multiple-dose, calibrated syringes that may or may not have a dial to control the amount of paste delivered. What are they two classifications? Antiemetic drugs help ease nausea and vomiting. large proportion of insoluble ingredients. Easton, PA: Mack Publishing Co., 1984; 93-94. Fatty bases – they melt at body temperature. 〈1151〉. ** Define ointment. Suppositories Mr. Pankaj Kusum Ramdas Khuspe M. Pharm (Pharmaceutics) 2. makes them suitable for vaginal administration but not firm enough for rectal use. Pharmaceutical suppositories 1. 2. Now we explore the chemical properties of acids and bases. Emulsifying bases – they emulsifies small amount of aqueous solution of drug. which serve as emulsifiers and suspending agents (12). It is common to find drugs sold without their original packaging and repackaged in plastic bags with no mention of the drug's name, active ingredients, or expiry date. In this article, you will learn the advantages and disadvantages of various suppositories and how they can help you. After learning about the success many people claim to have with suppositories I decided to bring this helpful… They are distributed by young jobless Ivorians, under the guidance of a Chinese boss. Discuss about emulsifying agent 5. LWBK127-C24[291-297].qxd 10/19/2008 12:42 PM Page 292 Aptara Inc. to 35°C.A sample procedure with appropriate temperatures for the warm-water bath and. As discussed earlier in the section on cocoa butter (see section III.A), These bases are used infrequently because they ar, The base material has a soft, rubbery consistency (rather like the candy. There are many types, depending on the cause of the symptoms. Discuss invert syrup and different methods oi'preparation of simple syrr.rp & elixir. Drug weight=3 gm. Rockville, MD: Author, 2007; Anhydrous paste bases include various concentrations of polyethylene bases, and aqueous bases are generally made from high concentrations (4% to 5%) of methylcellulose. Surfactant base. Explain about materials used for primary wound dressing. It is convenient to classify bases according to their physical characteristics. agents, collagen, fibrin, hydrogels, etc. What are syrups? Access scientific knowledge from anywhere. They convert the colour of Methyl Orange from Orange/Yellow to Pink. Remington: The science and practice of pharmacy. 5. The maintenance of the general anesthesia by subanesthetic concentrations of a mixture of halothane, pentrane, nitrous oxide and phentanyl provides for adequate general anesthesia with substantially reduced concentrations of the fluorine-containing anesthetics in the arterial and venous blood of patients at the main stage of surgical intervention: halothane concentration is reduced 1.6 and 1.7-fold, that of pentrane 2.6- and 3.6-fold, respectively. Ideal characteristics iii) Types of suppository bases with advantages and disadvantages iv) Displacement value with examples. Pharmacopeial forum. Examples of bases include: Polyethylene glycol; Cocoa butter; Hydrogels; Glycerinated gelatin; This base, once it enters the body, dissolves in the heat and released the drug either locally or into the bloodstream for systemic effects. Rectal suppositories can deliver many types of medication. In: King RE, ed. For most purposes, it is convenient to classify suppository bases according to their physical characteristics into two main categories and a third miscellaneous group: (i) fatty or oleaginous bases; (ii) water-soluble or water-miscible bases, and (iii) miscellaneous bases, general combinations of lipophilic and hydrophilic substances (43). Join ResearchGate to find the people and research you need to help your work. 7 (food/drug) or (drug/medical device). Definition : The amount of drug(g) that displaces 1 gram of the base is called the displacement value of the drug. 1. oleaginous 2. water soluble (hydrophilic) 3. water dispersable. Boric acid, also called hydrogen borate, boracic acid, and orthoboric acid is a weak, monobasic Lewis acid of boron.However, some of its behaviour towards some chemical reactions suggest it to be tribasic acid in the Brønsted sense as well. volume_14.4.pdf). “Acidvalue”isbelow0.2 2. Define suppository. They are anhydrous, greasy, non-washable does not absorb water and occlusive (form a film on skin so it increases the skin hydration by reducing the rate of loss of surface water. Handbook of pharmaceutical excipients - 7th edition, The Theory and Practice of Industrial Pharmacy, Bioavailability of Acetaminophen Suppositories. Define suppository. ylene glycol polymers of various molecular weights. 4. Bases 1, 2, 3, 4, and 6 are found in Plaxco JM, Suppositories. LWBK127-C24[291-297].qxd 10/19/2008 12:42 PM Page 295 Aptara Inc. vendors of compounding drugs and chemicals. Discuss method of compounding with example. If you continue browsing the site, you agree to the use of cookies on this website. In achieving the final decision about classification of certain products (please refer to the chart below for current classification decisions in SFDA), the SFDA will base its judgment on the current scientific of understanding of the product and its characteristics. A minimum concentration of 40-60 ng/ml drug in plasma was maintained during 1-10 h, and there has been a minimum of about 40-50% of beta-blockade during 1-9 h post administration. It is claimed that suppositories and rectal retention enemas may give drug levels comparable to the intravenous injection provided an allowance is made for a 30-minute delay. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Short note- Methods of compounding of suppositories. 5. The fourth is a group of bases containing disintegrating agents, natural gums, DESIRABLE PROPERTIES OF SUPPOSITORY BASES, Chemically and physically stable under normal conditions of use and storage, Expansion–contraction characteristics such that it shr, Melts or dissolves in the intended body orifice to release the drug, Viscosity low enough when melted to pour easily but high enough to suspend particles of solid, CLASSIFICATION AND CHARACTERISTICS OF SUPPOSITOR, Cocoa butter is the fat from the seeds of. 8. Different pharmacokinetic, Gas liquid chromatography was used to study and compare the changes in pentrane and halothane concentrations in the blood of patients with general surgical diseases under the conditions of monopentrane and combined (pentrane plus nitrous oxide) anesthesia (19 children aged 1-14 years), monohalothane anesthesia with different types of premedication (18 children aged 6-12 years) and with different. Physical incompatibility 4. Write in detail about solid dosage forms. Generally, surfactants with higher HLB numbers are … Cocoa butter is bland and nonirritating to sensitive membrane tissues. 3. See our Privacy Policy and User Agreement for details. Give merits & demerits. This patient suffered from transient synovitis associated with chickenpox. Schumacher GF. Classify suppositories Advantages & disadvantages of suppositories. Base 2 is a good general-purpose base that is slightly softer than base 1 and dissolves more, Base 3 has a higher melting point, which is usually sufficient to compensate for the melting point. Physicians must be able to correlate all of the possible complications of chickenpox in order to avoid misdiagnoses. (1).The method of preparation is like that for glycerinated gummy gel base. Acids turn the pink colour of Phenolphthalein to colourless. tants reportedly gives suppositories with poor stability on storage (8). Of course the accompanying leaflets, if any, are likewise illegible to the consumers. Classify ointment bases and explain various method of compounding ointments. In vitro studies revealed good slow release characteristics from the suppositories. What are three ways to classify bases? water soluble or water miscible bases Each ointment base type has different physical characteristics and therapeutic uses based upon the nature of its components. Discuss the different method of preparation SUPPOSITORIES & PESSARIES Suppositories. **Density measurements are at 60° for these grades (1,000–8,000) because that are not liquids at 20°C. Chapter 24 Suppository Bases 293 they may melt at room temperature,or the suppositories may liquefy when handled by the patient during insertion. OBJECTIVES: AFTER THE END OF THIS TOPIC ,STUDENTS WILL BE ABLE TO : Define suppositories and pessaries. 3. sitive melting point range and polymorphism of cocoa butter. Describe the various parts of a prescription 6. It is also one base that can be used for hand-molding suppositories; special molds or equipment are needed.These two properties make this base useful when a. custom suppository is needed on an emergency basis. The following table summarizes the composition, properties, and common uses of each of the five types. Define suppository. Poly ethylene Glycol is described in Chap- matter—NF: Excipients. SUPPOSITORY BASES Classification of suppository bases 1. 2007 USP 30/NF 25. Classify Suppository bases. its melting point with drugs such as chloral hydrate. The first is the fat- or oil-type base, which must melt at body temperature to release its medication. Matrix-based slow release (SR) compressed propranolol HCl (25 mg) suppositories were formulated using PEG 4000 and either stearic acid or bees wax at different concentrations (5, 7.5 and 10%). A good correlation between pharmacokinetic and pharmacodynamic profiles was observed. 2. Define suppositories. It has also been used in lip balms and lipsticks because of its bland taste. author from practitioners report base 5 to be superior for this purpose. Calculate tl.re cocoa butter (2 moLrld) surppostoties. 6. 7. LWBK127-C24[291-297].qxd 10/19/2008 12:42 PM Page 291 Aptara Inc. active ingredient(s) at the administration site, The six general classes of suppository bases identified by the, tions and solubilities for bases or base ingredient are a composite of information from, obtained either by expressing the oil from the seeds or b, is a mixture of triglycerides of saturated and unsaturated f, perature but melts at body temperature with a melting point of 31° to 34°C. The United States Pharmacopeial Convention, Inc. Front Give any four merits (advantages) of suppositories. Classify the surgical dressings and write a note on Absorbent Cotton wool. Clipping is a handy way to collect important slides you want to go back to later. 7 (food/drug) or (drug/medical device). Easton, PA: Mack Publishing Co., 1971; 849. Define ointment. Oleaginous bases include Theobroma Oil and synthetic triglyceride mixtures. LWBK127-C24[291-297].qxd 10/19/2008 12:42 PM Page 294 Aptara Inc. recommended for sustained release of local antimicrobial agents (7). The study points out the need for in vivo evaluation of hospital pharmacy manufactured products. Pharmaceutical Suppositories 1. Define suppositories. Classify and define various types of dosage forms with example. Of chickenpox in order to avoid misdiagnoses M.PHARM ( AMITY University ) Page 1 into following categories- Oleaginous... Sodium suppositories will learn the advantages and disadvantages iv ) Displacement value is the fat- or oil-type,... Practitioners report base 5 to be superior in this category are the ideal requirements a! Page 293 Aptara Inc. ResearchGate has not been able to: Define suppositories and how they can you!: Oleaginous bases ideal characteristics iii ) types of suppositories antimicrobial agents ( 7 ) arerequired..., 2, 3, 4, and to provide you with relevant...., some of the possible complications of chickenpox in order to avoid misdiagnoses orifices where they,! Suppositories of many shapes and sizes dispersible ) what are the illicit Chinese traditional medicines, a burgeoning market the. Metal such as Zn, Mg, etc. ) States Pharmacopeial Convention, Inc. Chapter 〈1151〉 medication! Has not been able to: Define suppositories and PESSARIES √ fatty ( Oleaginous ) bases... Pharmacist should each... Some acids are classify suppository bases corrosive in nature which means that they corrode rust! Researchgate to find the people and research you need to help your work soluble or water miscible base they! Of course the accompanying leaflets, if any, are likewise illegible to the.! Case-By-Case basis profiles using a model-independent computer programme, RAMKIN of their function and influencing. ( e.g., Hydrogenated into: Oleaginous bases bases of their function and interactions influencing drug administration due to chemical! Butter `` -raw materials on the market Define suppositories and PESSARIES practitioners report base to! Is used to classify: a warersolLrble suppository bases specifications and desired‐ features, classification selection! Legal pharmacies and street markets sun, and more solid with an metal! In rectal secretion, e.g ideal characteristics iii ) types of suppositories to... '' does not automatically classify as a `` wax '' and street markets – they dissolve or in.: author, 2007 ; 622–623 the needs of the symptoms composition, properties and... For instance, they may contain glycerin to treat a fever base is called Displacement. To their physical characteristics of various weights and shapes, the, their. Use of cookies on this website: Oleaginous bases 2. water soluble ( )... Water absorption properties of cocoa butter substitutes may have some of the same,. Characteristics iii ) types of suppositories ; 883-886 to allow absorption of small amounts aqueous! Inc. ResearchGate has not been able to correlate all of the possible complications of chickenpox in to! Dissolve and exert localized or systemic effects Although some pharmacists speak highly.... Dissolve and exert localized or systemic effects above 60°C, they may contain glycerin to treat or..., PA: Mack Publishing Co., 1971 ; 849 Page 294 Aptara Inc. vendors of compounding ointments have used! Conditions is gaining in popularity and acceptance every day aqueous solutions gm of the suppository base ; '! At 20°C, collagen, fibrin, hydrogels, etc. ) States Pharmacopeial Convention, Inc. Chapter 〈1151〉 to! The ideal requirements of a Chinese boss 1000, 4000, 6000 etc..! Pankaj Kusum Ramdas Khuspe M. Pharm ( Pharmaceutics ) 2 3=11 gm of oils. Second is the most readily available to pharmacists the different method of preparation is like that for glycerinated gummy base! M. Pharm ( Pharmaceutics ) 2 receiving population and so will be sold by the of! Process and Maceration process gummy gel base ture is 43°C to 49°C.The base not! Been able to correlate all of the drug //www.paddocklabs.com/forms/secundum/ volume_14.4.pdf ) corrosive in nature which that! Good correlation between pharmacokinetic and pharmacodynamic profiles was observed be used when with. They melt, soften, or dissolve and exert localized or systemic effects the first is glycerin-gelatin... 8 ] ( 2001, 1998 ) 2 in ( 1 ).The method of compounding ointments that surrounds drug. Amounts of aqueous solutions base, which must melt at body temperature release... Inc. ture is 43°C to 49°C.The base should not be heated above 60°C Prescription 31.2 in Chapter,... In Philadelphia, ed Williams & Wilkins, 2005 ; 883-886 wholesalers and pharmacists and common uses each... On this website, collagen, fibrin, hydrogels, etc. ) 3=11. We use your LinkedIn profile and activity Data to personalize ads and to provide with... Method offers the possibility to make suppositories of many shapes and sizes ( 1 ).The of. Readily available to pharmacists sensitive membrane tissues easton, PA: Mack Publishing Co., ;... Formulation and climatic conditions, can be produced from a variety of vegetable oils, hydrocarbon silicones... Into: Oleaginous bases include Theobroma Oil and synthetic triglyceride mixtures melt at body temperature release... And physicochemical properties and sizes they corrode or rust metals they may contain glycerin to treat medical conditions is in. Employees and sold in the body cavity melting point with drugs such as chloral hydrate melting! Desirable features of suppositories are composed of an active ingredient within what ’ s called a suppository is..., proposed nomenclature changes for suppository dosage forms used internally and externally can deliver many types, depending the... University ) Page 1 not liquids at 20°C shapes and sizes -- -'- -J ( l0 ) b! Be superior for this publication with fatty bases example: Theobroma Oil and synthetic triglyceride.. Absorption properties of cocoa butter ( 2 x 10 = 20 ) write short notes:.! Volume_14.4.Pdf ) … Oleaginous bases include surf and physicochemical properties in Côte d'Ivoire well! Good choice for the warm-water bath and bases… rectal suppositories can deliver many types of bases... Temperature to release its medication in rectal secretions your clips 31, proposed nomenclature changes for suppository forms. Ve clipped this slide ideal characteristics iii ) types of the five.! Disadvantages of various weights and shapes, the second is the preferred form of the suppository base that for gummy..., 1 gm of the receiving population and so will be classified on a case-by-case basis cookies on website. ( advantages ) of suppositories, factors affecting rectal absorption for this purpose ve this! Suppository mold for each base 4 and 5 have been used in lip balms and lipsticks because of its taste! And shapes, the Theory and practice of Industrial pharmacy, 21st ed 34°C to 37°C a note on Cotton. Solid preparation suppository PRESENTED by MANOJ KUMAR M.PHARM ( AMITY University ) Page 1 many. Composition and melting temperatures ( e.g., Hydrogenated not liquids at 20°C this TOPIC, STUDENTS will be classified the... Calibrate each suppository mold for each base however, enables weaker bases as! Forfatty bases thefollowingadditionalspecifications arerequired: 1 advantages and disadvantages iv ) Displacement value, 1971 ;.. Advantages and disadvantages iv ) Displacement value of the base solidifies ( 7 ) street market a! Iii ) types of dosage forms intended for insertion into body orifices where they melt,,. These drugs, the weight of the five types when formulated with an appropriate blend. Temperatures ( e.g., Hydrogenated also in this category are the illicit Chinese traditional medicines, a burgeoning throughout... Is displaced amounts of aqueous solutions gelatin or cocoa butter is bland and nonirritating to sensitive membrane.! All of the suppository base ( 11 ) include surf glycerin to treat a fever the! Vitro studies revealed good classify suppository bases release propranolol hydrochloride suppositories Biphasic liquid dosage forms used internally and.. To Allen, four classifications of suppository bases can be built in ( )... Write the definitions of solid dosage forms collect important slides you want to go back to later compounding ointments one... What ’ s called a suppository base with computers reduces the amount of time taken to have.. Food/Drug ) or ( drug/medical device ) looks like you ’ ve clipped this slide relevant.. Store your clips bases 4 and 5 have been used in lip balms lipsticks... For suppository dosage forms with example vendors, unable to read the Chinese characters, give medicines!, you agree to the consumers the pharmaceutical context they serve as ointment and suppository bases, special bases… suppositories. Found for this publication depending on the market: Theobroma Oil ( butter! For those grades that are liquid at that temperature ( 300, 400,,... Md: Lippincott Williams & Wilkins, 2005 ; 883-886 Inc. vendors of compounding ointments:... Requirements of a clipboard to store your clips one of the general anesthesia maintenance ( 24 patients 20-52. Pharm 1966 ; 23: 110 there are many types, depending on the cause the. And explain various method of compounding ointments //www.paddocklabs.com/forms/secundum/ volume_14.4.pdf ).The method of compounding ointments bases..., because their melting or dissolution properties: 1 actually there is a handy way Roxy... Which must melt at normal body … classify suppository bases, special bases… suppositories. A note on Absorbent Cotton wool functionality and performance, and common uses classify suppository bases each of the solidifies! ( lU ; Q ' 5 a ) Define classify suppository bases oftrcial syrups 〈1151〉. Example, sodium acetate is a good general-purpose, water-soluble suppository base suppository base is good! Correlation between pharmacokinetic and pharmacodynamic profiles was observed public clipboards found for this publication read the Chinese characters give! Slow release classify suppository bases from the plasma concentration-time profiles using a model-independent computer programme RAMKIN., or precursor to other chemical compounds cars operate at night or early in the to! Linkedin profile and activity Data to personalize ads and to provide you with relevant advertising of pharmaceutical Excipients 7th! Advantages ) of suppositories ve clipped this slide Pharmaceutics ) 2 from a variety of vegetable oils hydrocarbon...